Elisa Roncati Zanier MD
Elisa R. Zanier trained in Medicine, Anaesthesia and Intensive Care at the University of Milano. She was a Post-doctoral fellow at the Neurotrauma Laboratory, University of Los Angeles, California. She was consultant at the Neuro-Intensive Care Unit, Fondazione IRCCS Ospedale Maggiore Policlinico, Milano from 2003-2007. Since 2007, she has a teaching assignment into postgraduate school of Intensive Care and Anesthesiology, University of Milano. Since 2007, she is associate researcher at the Mario Negri Institute, Milano, Italy. From 2012-2016 she leaded the Unit of Acute Brain Injury and Cell Therapy, now she is Head of the Laboratory of Acute Brain Injury and Therapeutic Strategies.
Acute brain injury can have severe and long-lasting consequences. Pharmacological neuro-protection, both for traumatic brain injury (TBI) or hemorrhagic lesions, is not available, with repeated failures of several International trials. There is a gap from successful experimental interventions in animal models and failures in clinical applications. Essential for our research, therefore, is a lively connection/interplay between the laboratory and the clinical work. Parallel exploration of mechanisms in the clinical setting (through invasive monitoring and neuro-imaging, for instance) and in the lab could refine experimental models and develop neurorestorative treatments.
Specific aims of the program:
· To understand the mechanisms transforming an initial acute biomechanical injury into a chronic and progressive pathology.
· To understand the heterogeneity of TBI and identify biomarkers for acute brain injury
· To interfere with injury evolution by reducing toxic events and fostering the endogenous reparative response.
Elisa R Zanier is a member of the Editorial Board of Frontiers in Immunology and Intensive Care Medicine Experimental.